Pharmacogenomics Testing Confirmation of Carbamazepine Induced DRESS Reaction of an HLA-A*31:01 Positive, Polypharmacy Patient

  • Leigh Speicher Mayo Clinic Florida
  • Sheena Crosby Mayo Clinic Florida
  • Michael J. Schuh Mayo School of Health Related Sciences
Keywords: pharmacogenomics, polypharmacy, collaboration, HLA, DRESS


Pharmacogenomics (PGx) melds well with polypharmacy as another tool to identify medication related problems (MRPs) more specifically so they may be solved most effectively. PGx can pre-emptively assist in medication selection, medication dosing or identify better medications for patients already taking a medication.  PGx can also confirm suspect medications of causing MRPs such as adverse drug reactions (ADRs) or drug interactions. In this case, PGx testing confirmed presence of a serious human leukocyte antigen (HLA) drug reaction with eosinophilia and systemic symptoms (DRESS) after a suspect medication had been stopped.


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Received 2021-08-24
Accepted 2021-09-16
Published 2021-12-13
Pharmacy Practice & Practice-Based Research