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2021-12-13
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Pharmacy Practice & Practice-Based Research
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Copyright (c) 2021 Leigh Speicher, Sheena Crosby, Michael J. Schuh
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright of content published in INNOVATIONS in pharmacy belongs to the author(s).
Pharmacogenomics Testing Confirmation of Carbamazepine Induced DRESS Reaction of an HLA-A*31:01 Positive, Polypharmacy Patient
Leigh Speicher
Mayo Clinic Florida
Sheena Crosby
Mayo Clinic Florida
Michael J. Schuh
Mayo School of Health Related Sciences
DOI: https://doi.org/10.24926/iip.v12i4.4341
Keywords: pharmacogenomics, polypharmacy, collaboration, HLA, DRESS
Abstract
Pharmacogenomics (PGx) melds well with polypharmacy as another tool to identify medication related problems (MRPs) more specifically so they may be solved most effectively. PGx can pre-emptively assist in medication selection, medication dosing or identify better medications for patients already taking a medication. PGx can also confirm suspect medications of causing MRPs such as adverse drug reactions (ADRs) or drug interactions. In this case, PGx testing confirmed presence of a serious human leukocyte antigen (HLA) drug reaction with eosinophilia and systemic symptoms (DRESS) after a suspect medication had been stopped.
