Wolbachia Infections and Their Impact on Outbreaks of Yellow Fever Virus

Natalie Bontrager

University of Minnesota School of Public Health


Abstract

Yellow Fever Virus is responsible for 30,000 human deaths annually in the equatorial regions of Africa and South America.  Due to frequent urban outbreaks and a shortage of Yellow Fever vaccines new control measures are necessary to protect the health of humans.  This paper is a review of current research regarding the potential use of Wolbachia bacteria as a biocontrol for the largest human vector of Yellow Fever Virus, the Aedes aegypti mosquito.  Wolbachia has been shown to be effective in preventing transmission of other RNA Flaviviridae diseases such as Zika Virus, Dengue Fever and Chikungunya. Due to the cost-effectiveness and ease of implementing Wolbachia infections into Aedes aegypti populations it is a recommended control effort against Yellow Fever Virus transmission.