Overcoming tamoxifen resistance: A primer for “Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen”
Jennifer Thomalla
Abstract
To discuss and explain Hurtado et al. (2008) “Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen” which offers a description of the regulation of the ERBB2 gene at the transcriptional level. Tamoxifen resistance can occur via crosstalk between ER/ERBB2. Understanding the regulation of ERBB2 enables researchers to develop methods to knockdown expression of ERBB2, thus decreasing the amount of ER/ERBB2 crosstalk ultimately restoring tamoxifen sensitivity.
